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Inline Particle Sizing in Flow for Demanding Nanosuspension Processes
Achieving accurate, real-time particle size analysis in highly concentrated, flowing nanosuspensions has long posed a major challenge in nanoparticle manufacturing and formulation. In this whitepaper, we present how Spatially Resolved Dynamic Light Scattering (SR-DLS), implemented in the NanoFlowSizer, enables continuous, non-invasive measurement of silica nanoparticle size and polydispersity—even under demanding process conditions with high turbidity, elevated flow rates (up to 300 L/h), and a wide temperature range. This breakthrough allows quality-critical parameters to be monitored inline, without sample extraction or dilution.
Discover how the NanoFlowSizer delivers robust size characterization during processing, unlocking valuable insights into flow behavior, shear limits, and process stability in real time. By overcoming key limitations of conventional DLS methods, SR-DLS opens new possibilities for process analytical technology (PAT) in both research and industrial production environments.
“Save time, save money, control production processes.”